Piron's axioms for a realistically interpreted quantum mechanics are analyzed in detail within the context of a formal mathematical structure expressed in the conventional set-theoretic idiom of mathematics. As a result, some of the serious misconceptions that have encouraged recent criticisms of Piron's axioms are exposed.

Using 94 published empirical articles in academic journals as a data base, this paper provides a critical review of the methodology employed in the study of ethical beliefs and behavior of organizational members. The review revealed that full methodological detail was provided in less than one half of the articles. Further, the majority of empirical research articles expressed no concern for the reliability or validity of measures, were characterized by low response rates, used convenience samples, and did not offer a (...) theoretic framework, hypotheses, or a definition of ethics. Several recommendations, including a reviewer rating form addressing methodological decisions and inclusion of methodologists on the review panel, are offered to improve methodological rigor in published ethics research. (shrink)

There has been considerable debate in the literature about the relative merits of information processing versus dynamical approaches to understanding cognitive processes. In this article, we explore the relationship between these two styles of explanation using a model agent evolved to solve a relational categorization task. Specifically, we separately analyze the operation of this agent using the mathematical tools of information theory and dynamical systems theory. Information-theoretic analysis reveals how task-relevant information flows through the system to be combined into a (...) categorization decision. Dynamical analysis reveals the key geometrical and temporal interrelationships underlying the categorization decision. Finally, we propose a framework for directly relating these two different styles of explanation and discuss the possible implications of our analysis for some of the ongoing debates in cognitive science. (shrink)

Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla–Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error (...) computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor. Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold. (shrink)

This book evaluates the claim that in order to explore the changing social foundations of global power relations today, we need to include in our analysis an understanding of global civil society, particularly if we also wish to raise ethical questions about the changing political and institutional practices of transnational governance. The authors engage directly with the notion of global civil society in order to examines the ethical, social, and political conditions that make certain kinds of globalizing practices a reality (...) today. They explore and utilize the normative dimensions of the civil discourse to further debate about the meaning of citizenship in a world of multi-level governance, as well as the changing characteristics of political community and democracy. Bridging the normative concerns of political theorists with the historical and institutional focus of scholars of international relations and international political economy, this book will be of broad interest to students and researchers concerned with international relations, civil society, global governance and ethics. (shrink)

The title of this paper represents a "trick question" of the sort an interlocutor might employ to solicit an answer which, if framed with specific regard to the question's implicatures, cannot fail to confirm that interlocutor's position or further his aims. The best-known query of this form is the cliched "Do you still beat your spouse?" To escape being trapped, the respondent must either (a) avoid answering or (b) point out and refute the implication(s) embedded in the question itself. In (...) practice, both options typically entail risk. Option (a) may violate the procedural form of the "language game" (cf. Wittgenstein, 1963) within which the question occurs, while option (b) may violate the thematic or orientational focus presumed or enacted in that language game. This paper is intended to outline a "trick question" (that of the title) which has over the years been a recurrent challenge slung at adherents of the theories which have brought us together here in Belo Horizonte. If the following text accomplishes my intentions, it will explain the challenge, assess our response(s) to date, and offer suggestions about what (if any) further action it may prudently motivate. (shrink)

A comprehensive formal system is developed that amalgamates the operational and the realistic approaches to quantum mechanics. In this formalism, for example, a sharp distinction is made between events, operational propositions, and the properties of physical systems.

van Gelder argues that computational and dynamical systems are mathematically distinct kinds of systems. Although there are real experimental and theoretical differences between adopting a computational or dynamical perspective on cognition, and the dynamical approach has much to recommend it, the debate cannot be framed this rigorously. Instead, what is needed is careful study of concrete models to improve our intuitions.

The referential focus of this paper is not a hypothesis or theoretical point per se. Instead, it is the body of work (hereafter termed autopoietic theory) developed by Humberto Maturana and Francisco Varela. The intended audience is not a community of critical scholars per se. Instead it is the "community of interest" for whom autopoietic theory is at least an object of interest and at most an object of personal commitment. To the extent autopoietic theory has prospered and spread over (...) the last quarter century, it has often been a function of highly interactive, even personal, relationships among self-acknowledged adherents and those generally interested. Owing to the distribution of such correspondents across diverse disciplines, their cohesion as a "community" has been tenuous at best. I wish to step back from the usual scholarly perspective and use this venue to address what may be termed the pragmatics of autopoietic theory. The intention is to offer some sort of "state of the community" assessment, recommendations, and / or tips regarding: (a) autopoietic theory's documentary corpus; (b) discourse on autopoietic theory; and (c) applying the theory in the context of focused research. The goal is to help orient newcomers and provoke reflection among the "veterans.". (shrink)

In the history of Western thought, Christian theology was once considered to be 'the Queen of Sciences'. Today it has been marginalised by a prevailing scepticism. Randal Rauser confronts the problem of developing a public voice for the theologian as engaged in true theological science while not compromising the commitment to the Christian community of faith. This book posits a viable account of theological rationality, justification, and knowledge that avoids the twin pitfalls of modern rationalism and postmodern irrationalism. Theology is (...) freshly understood as a rigorous and rational truth-seeking discipline that seeks theoretical understanding of divine reality. Throughout the modern era the predominant epistemological position has been classical foundationalism, a position now widely rejected by philosophers and theologians alike. Philosophers recognize that it fails to achieve a plausible account of rationality, justification or knowledge, while theologians recognize the extent to which classical foundationalist strictures have distorted Christian doctrine. In its place many philosophers and theologians alike have adopted a nonfoundationalist epistemology, which is in turn often associated with a problematic alethic and metaphysical antirealism. Engaging with the ideas of key thinkers from Descartes, Locke, and Kant, to Bruce Marshall and Alvin Plantinga, Rauser provides an accessible and provocative survey of the theological terrain of the modern - and postmodern - era, arguing in favour of a return to a moderate foundationalism. (shrink)

In orthodox quantum mechanics, it has virtually become the custom to identify properties of a physical system with operationally testable propositions about the system. The causes and consequences of this practice are explored mathematically in this paper. Among other things, it is found that such an identification imposes severe constraints on the admissible states of the physical system.

This paper reviews the fate of the central ideas behind the complementary learning systems (CLS) framework as originally articulated in McClelland, McNaughton, and O’Reilly (1995). This framework explains why the brain requires two differentially specialized learning and memory systems, and it nicely specifies their central properties (i.e., the hippocampus as a sparse, pattern-separated system for rapidly learning episodic memories, and the neocortex as a distributed, overlapping system for gradually integrating across episodes to extract latent semantic structure). We review the application (...) of the CLS framework to a range of important topics, including the following: the basic neural processes of hippocampal memory encoding and recall, conjunctive encoding, human recognition memory, consolidation of initial hippocampal learning in cortex, dynamic modulation of encoding versus recall, and the synergistic interactions between hippocampus and neocortex. Overall, the CLS framework remains a vital theoretical force in the field, with the empirical data over the past 15 years generally confirming its key principles. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This chapter argues that the objection that Socrates makes against diviners, poets, and rhapsodies having knowledge is an example of what has come to be known as an opacity objection: that is, some aspect of what would be required for them to know is unrecognised by them. This chapter contends that the opacity is of a different kind than what contemporary epistemologists have considered, and claims that Socrates’ specific version should have a place in contemporary theory of knowledge.

In this article, I consider the famous Invisible Gardener Parable which aims to show that theism is not a viable theory because it can be endlessly amended to accommodate for prima facie disconfirming data. I point out that the parable fails to consider how tolerance for theory adjustment is relative to the perceived explanatory power of the theory. I also point out that naturalism is no less subject to adaptation than is theism. Thus, if endless adaptability constitutes an objection for (...) theism then it does so for naturalism as well. (shrink)

Late in 1990, the Center for the Study of Ethics in the Professions at Illinois Institute of Technology (lIT) received a grant of more than $200,000 from the National Science Foundation to try a campus-wide approach to integrating professional ethics into its technical curriculum.! Enough has now been accomplished to draw some tentative conclusions. I am the grant's principal investigator. In this paper, I shall describe what we at lIT did, what we learned, and what others, especially philosophers, can learn (...) from us. We set out to develop an approach that others could profitably adopt. I believe that we succeeded. (shrink)

© 2015 Elsevier Inc.Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within an intracellular parasitophorous vacuole that is selectively permeable to small molecules through unidentified mechanisms. We have identified GRA17 as a Toxoplasma-secreted protein that localizes to the parasitophorous vacuole membrane and mediates passive transport of small molecules across the PVM. GRA17 is related to the putative Plasmodium translocon protein EXP2 and conserved across PV-residing Apicomplexa. The PVs of GRA17-deficient parasites have aberrant morphology, reduced permeability to (...) small molecules, and structural instability. GRA17-deficient parasites proliferate slowly and are avirulent in mice. These GRA17-deficient phenotypes are rescued by complementation with Plasmodium EXP2. GRA17 functions synergistically with a related protein, GRA23. Exogenous expression of GRA17 or GRA23 alters the membrane conductance properties of Xenopus oocytes in a manner consistent with a large non-selective pore. Thus, GRA17 and GRA23 provide a molecular basis for PVM permeability and nutrient access. (shrink)

Acute exercise consistently benefits both emotion and cognition, particularly cognitive control. We evaluated acute endurance exercise influences on emotion, domain-general cognitive control, and the cognitive control of emotion, specifically cognitive reappraisal. Thirty-six endurance runners, defined as running at least 30 miles per week with one weekly run of at least 9 miles (21 female, age 18-30 years) participated. In a repeated measures design, participants walked at 57% age-adjusted maximum heart rate (HRmax) (range 51-63%) and ran at 70% HRmax (range 64-76%) (...) for 90 minutes on two separate days. Participants completed measures of emotional state and the Stroop test of domain-general cognitive control before, every 30 minutes during, and 30 minutes after exercise. Participants also completed a cognitive reappraisal task after exercise. Functional near-infrared spectroscopy tracked changes in oxygenated and deoxygenated hemoglobin levels in the prefrontal cortex (PFC). Endurance exercise elevated positive emotion and cognitive reappraisal success. Endurance exercise reduced Stroop response time and test-evoked PFC oxygenation during exercise. Results suggest that even at relatively moderate intensities, endurance athletes benefit emotionally from running both during and after exercise, and task-related prefrontal cortex oxygenation reductions do not appear to hinder prefrontal-dependent cognitive control. (shrink)

The rise of the phenomenon of virtue ethics in recent years has increased at a rapid pace. Such an explosion carries with it a number of great possibilities, as well as risks. This volume has been written to contribute a multi-faceted perspective to the current conversation about virtue. Among many other thought-provoking questions, the collection addresses the following: What are the virtues, and how are they enumerated? What are the internal problems among ethicists, and what are the objections and replies (...) to contemporary virtue ethics? Additionally, the practical implications following from the answers to these questions are discussed in new and fascinating research. Fundamental concepts such as teleology and eudaimonism are addressed from both a historical and dialectical approach. This tome will contribute not only to providing further clarity to the current horizons in virtue ethics, but also to the practical conclusion following from the study: to challenge the reader toward a greater pursuit of the virtuous life. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy of Music Education Review 13.1 (2005) 104-108 [Access article in PDF] A Response to Estelle R. Jorgensen, "Four Philosophical Models of the Relationship Between Theory and Practice" Randall Everett Allsup Teachers College, Columbia University Each of the four philosophical models that Estelle Jorgensen has put forth contests, adheres to, or adjusts the hierarchical relationships between dualities, specifically the theory and practice of musical learning. The dichotomy model (...) faces binary associations head on, splitting existence however defined into dualisms like "this/that," "us/them," and "mind/body." Models of polarity, according to Jorgensen, accommodate dualities by buffering edges, emphasizing the interconnectedness of binary relationships. The fusion metaphor is exemplified by Paulo Freire's notion of praxis in which action and reflection are welded together to create hope for a new world, one free of the oppression and conflict that is inherent in binary relationships. The dialectical model is contrapuntal by nature, Edward Said would say.1This relationship highlights our postmodern devotion to différence by embracing the tension created through inclusion so that "this is with that," "we are with them and they are with us," and "mind is with body, just as body is with mind."2Perhaps there is a fifth model, a new kind of relationship where the oppositional or hierarchical nature of binaries co-exists peacefully without tension. [End Page 104] Such an arrangement is, I think, an outgrowth of capitalist democracy—it is, most especially, representative of our global, information age. This type of relationship is problematic philosophically, we will see, lacking as Jorgensen has outlined "logic evidenced in principles," "internal consistency," and "coherence within a unity or whole." Likewise for Bennett Reimer, this new mind-set fails the test of philosophical scrutiny, unconcerned as it is with a "reasoned, structured set of propositions."3 Whether philosophy or mind-set, this new arrangement has as much to do with freedom and free markets as it does with the particular conditions of both modernity and postmodernity.In the novel, White Noise, by Don DeLillo, the postmodern condition is represented in part by an "Airborne Toxic Event," a cloud of gas, Nyodene D, which floats above a tranquil All-American college town.4 A sense of crisis is felt, but felt obliquely and no one knows exactly what harm has been done. In Albert Camus' The Plague, by contrast, the disease that infests the North African town of Oran acts to awaken its citizenry, confronting the populace with the moral imperatives to fight or flee.5 Perhaps the metaphor of quarantine symbolizes the hard boundaries of modernism.Capitalism seeks to dissolve conflict. It operates silently, in the realm of social production, like a cloud of gas. Denise, Jack Gladney's daughter in White Noise, mumbles over and over in her sleep, "Toyota Corolla, Toyota Celica, Toyota Cressida...."6 There is a sense of ontological change, that the expanding reach of media, information, and technology rewires the way we think, the way we dream. Tensions are willed away. The expansion and survival of market shares, after all, depend on the peaceful erosion of boundaries—boundaries that demarcate what we learn, what we buy, and who we are.Questions about what this new system means—this new mind-set—are explored in a book called Empire by Michael Hardt and Antonio Negri.7 These writers posit a global world of communication, cooperation, and affect, where an increase in hybrids creates a kind of "omniversality" where the virtual, natural, and ideological converge.8 In the dialectical relationship that Jorgensen shares with writers like Paulo Freire and Maxine Greene, there is no acceptable synthesis, no peaceful co-existence, between oppressors and oppressed. While according to Freire, the oppressed may internalize or house characteristics of the oppressor. In the global world of capital, the oppositional nature of the Other is replaced by niches or fragments, dissolving differences into marketing opportunities, really. That the avant-garde no longer exists is proof of this new state.As the essentialist nature of the Other fades away... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy of Music Education Review 13.1 (2005) 104-108 [Access article in PDF] A Response to Estelle R. Jorgensen, "Four Philosophical Models of the Relationship Between Theory and Practice" Randall Everett Allsup Teachers College, Columbia University Each of the four philosophical models that Estelle Jorgensen has put forth contests, adheres to, or adjusts the hierarchical relationships between dualities, specifically the theory and practice of musical learning. The dichotomy model (...) faces binary associations head on, splitting existence however defined into dualisms like "this/that," "us/them," and "mind/body." Models of polarity, according to Jorgensen, accommodate dualities by buffering edges, emphasizing the interconnectedness of binary relationships. The fusion metaphor is exemplified by Paulo Freire's notion of praxis in which action and reflection are welded together to create hope for a new world, one free of the oppression and conflict that is inherent in binary relationships. The dialectical model is contrapuntal by nature, Edward Said would say.1This relationship highlights our postmodern devotion to différence by embracing the tension created through inclusion so that "this is with that," "we are with them and they are with us," and "mind is with body, just as body is with mind."2Perhaps there is a fifth model, a new kind of relationship where the oppositional or hierarchical nature of binaries co-exists peacefully without tension. [End Page 104] Such an arrangement is, I think, an outgrowth of capitalist democracy—it is, most especially, representative of our global, information age. This type of relationship is problematic philosophically, we will see, lacking as Jorgensen has outlined "logic evidenced in principles," "internal consistency," and "coherence within a unity or whole." Likewise for Bennett Reimer, this new mind-set fails the test of philosophical scrutiny, unconcerned as it is with a "reasoned, structured set of propositions."3 Whether philosophy or mind-set, this new arrangement has as much to do with freedom and free markets as it does with the particular conditions of both modernity and postmodernity.In the novel, White Noise, by Don DeLillo, the postmodern condition is represented in part by an "Airborne Toxic Event," a cloud of gas, Nyodene D, which floats above a tranquil All-American college town.4 A sense of crisis is felt, but felt obliquely and no one knows exactly what harm has been done. In Albert Camus' The Plague, by contrast, the disease that infests the North African town of Oran acts to awaken its citizenry, confronting the populace with the moral imperatives to fight or flee.5 Perhaps the metaphor of quarantine symbolizes the hard boundaries of modernism.Capitalism seeks to dissolve conflict. It operates silently, in the realm of social production, like a cloud of gas. Denise, Jack Gladney's daughter in White Noise, mumbles over and over in her sleep, "Toyota Corolla, Toyota Celica, Toyota Cressida...."6 There is a sense of ontological change, that the expanding reach of media, information, and technology rewires the way we think, the way we dream. Tensions are willed away. The expansion and survival of market shares, after all, depend on the peaceful erosion of boundaries—boundaries that demarcate what we learn, what we buy, and who we are.Questions about what this new system means—this new mind-set—are explored in a book called Empire by Michael Hardt and Antonio Negri.7 These writers posit a global world of communication, cooperation, and affect, where an increase in hybrids creates a kind of "omniversality" where the virtual, natural, and ideological converge.8 In the dialectical relationship that Jorgensen shares with writers like Paulo Freire and Maxine Greene, there is no acceptable synthesis, no peaceful co-existence, between oppressors and oppressed. While according to Freire, the oppressed may internalize or house characteristics of the oppressor. In the global world of capital, the oppositional nature of the Other is replaced by niches or fragments, dissolving differences into marketing opportunities, really. That the avant-garde no longer exists is proof of this new state.As the essentialist nature of the Other fades away... (shrink)

In this article, the author examines the seemingly privileged position of technology in current educational thought. The article begins by considering Lewis Mumford’s notion of the myth of the machine and his insistence that only when tool making/using is modified by linguistic symbols, esthetic design, and socially transmitted knowledge does it become a significant contributor to human development. Through a sociohistorical critique, the author establishes a relationship between the ubiquity of the mythos and current educational discourse. The author provides examples (...) from various historical events that have contributed to (a) the tradition of print-based culture, (b) the origins of the mythos of technology, (c) the increasingly popular notion that technology offers apanacea for educational woes, (d) the marginalization of critical discourse in regard to educational technology, and (e) corporate involvement in maintenance of the mythos. (shrink)

To explore the realm of creativity, we will make use of the concept of instauration as articulated in the work of Étienne Souriau. Although infrequently used, the word remains extant in English, with agreement among dictionaries that the primary definition is the action of restoring or renewing, with a secondary meaning of instituting or founding. While both senses are at play in Souriau’s thought, it is perhaps the tension between the two that is predominantly in question, akin to what we (...) describe as open containment. We think instauration, as institutive renewal, in dialogue with Merleau-Ponty’s late use of the term aesthesiology to further elaborate the process of creating as a return to the wonder that is aesthesis, the affectively and sensually apprehended opening onto and entanglement with what is. Merleau-Ponty extends aesthesiology as the science of the sense organs themselves into a philosophical organology for ontology. His use of aesthesiology and Souriau’s use of instauration constitute efforts to offer sufficient conceptual containment to be able to say the contingent and ambiguous open of ongoing originating, even while both thinkers strive not to institute any final closure by this very act of naming. This is the inevitable tension of writing philosophic creation.Pour explorer le royaume de la créativité, nous utilisons ici le concept d’instauration tel qu’il a été articulé dans l’oeuvre d’Étienne Souriau. Quoique utilisé rarement, ce terme est attesté dans la langue anglaise. Les dictionnaires anglais accordent que sa définition principale désigne une action de rétablissement ou de renouvellement, avec un sens secondaire d’institution ou fondation. Si les deux sens sont à l’oeuvre chez Souriau, c’est peut-être la tension entre eux qui y est surtout patente. Nous pensons ici l’instauration, entendue comme renouvellement instituant, en dialogue avec l’idée d’esthésiologie telle que Merleau-Ponty la comprend à la fin de son oeuvre. Il utilise cette notion pour développer sa conception du processus de création comme retour à l’étonnement que produit l’áisthesis. L’áisthesis est en effet l’ouverture, affective et sensible, et l’entrelacs, affectif et sensible, à ce qui est. Merleau-Ponty prolonge ainsi l’esthésiologie entendue comme science des organes sensibles, vers une organologie philosophique à visée ontologique. L’usage de l’esthésiologie chez Merleau-Ponty et l’usage de l’instauration chez Souriau constituent des efforts vers une maîtrise conceptuelle suffisante pour pouvoir dire l’ouverture continue, contingente et ambiguë de l’originaire – bien que les deux penseurs ne visent pas à instaurer une clôture finale à partir de l’acte nominatif. Telle est la tension inévitable qu’on rencontre lorsqu’on cherche à écrire la création philosophique.Utilizzeremo in queste pagine per esplorare il regno della creatività il concetto di “instaurazione” così come si trova articolato nell’opera di Étienne Souriau. Benché impiegato raramente, questo termine è attestato anche nella lingua inglese. I dizionari inglesi danno come significato principale quello di un’azione di ristabilimento o rinnovamento, a cui si aggiunge un significato secondario di istituzione o fondazione. Se è vero che entrambi i significati sono all’opera in Souriau, è d’altra parte ancor più evidente la loro tensione. Proporremo qui di pensare l’instaurazione, intesa come rinnovamento istituente, in dialogo con l’idea di estesiologia così come la intende Merleau-Ponty alla fine del suo percorso. Egli usa questa nozione per sviluppare la sua concezione del processo creativo come ritorno allo stupore dell’áisthesis, cioè dell’apertura affettiva e sensibile, e dell’intreccio affettivo e sensibile, a ciò che è. Merleau-Ponty prolunga così l’estesiologia come scienza degli organi di senso in direzione di un’organologia filosofica orientata ontologicamente. L’indagine sull’estesiologia condotta da Merleau-Ponty e l’uso del concetto di instaurazione in Souriau costituiscono così altrettanti sforzi di dire concettualmente l’apertura continua, contingente e ambigua dell’originario – benché sia chiaro che i due pensatori non intendono raggiungere in alcun modo, con questo dire concettuale e con questa scelta lessicale, una qualsiasi “chiusura” della questione. Tale è infatti la tensione inevitabile cui ci si ritrova esposti quando si tenta di scrivere la creazione. (shrink)

This paper consists of three parts supplementing the papers of K. Hauser 2002 and D. Mumford 2000: There exist regular open sets of points in with paradoxical properties, which are constructed without using the axiom of choice or the continuum hypothesis. There exist canonical universes of sets in which one can define essentially all objects of mathematical analysis and in which all our intuitions about probabilities are true. Models satisfying the full axiom of choice cannot satisfy all those intuitions and (...) they violate them in a very similar way as those models which satisfy also the continuum hypothesis. (shrink)

Background: Electroconvulsive therapy is one of the most effective treatments for major depressive disorder. Recently, there has been increasing attention to evaluate the effect of ECT on resting-state functional magnetic resonance imaging. This study aims to compare rs-fMRI of depressive disorder patients with healthy participants, investigate whether pre-ECT dynamic functional network connectivity network estimated from patients rs-fMRI is associated with an eventual ECT outcome, and explore the effect of ECT on brain network states.Method: Resting-state functional magnetic resonance imaging data were (...) collected from 119 patients with depression or depressive disorder, and 61 healthy participants, with an age mean of 52.25 years old. The pre-ECT and post-ECT Hamilton Depression Rating Scale were 25.59 ± 6.14 and 11.48 ± 9.07, respectively. Twenty-four independent components from default mode and cognitive control network were extracted, using group-independent component analysis from pre-ECT and post-ECT rs-fMRI. Then, the sliding window approach was used to estimate the pre-and post-ECT dFNC of each subject. Next, k-means clustering was separately applied to pre-ECT dFNC and post-ECT dFNC to assess three distinct states from each participant. We calculated the amount of time each subject spends in each state, which is called “occupancy rate” or OCR. Next, we compared OCR values between HC and DEP participants. We also calculated the partial correlation between pre-ECT OCRs and HDRS change while controlling for age, gender, and site. Finally, we evaluated the effectiveness of ECT by comparing pre- and post-ECT OCR of DEP and HC participants.Results: The main findings include depressive disorder patients had significantly lower OCR values than the HC group in state 2, where connectivity between cognitive control network and default mode network was relatively higher than other states, Pre-ECT OCR of state, with more negative connectivity between CCN and DMN components, is linked with the HDRS changes. This means that those DEP patients who spent less time in this state showed more HDRS change, and The post-ECT OCR analysis suggested that ECT increased the amount of time DEP patients spent in state 2.Conclusion: Our finding suggests that dynamic functional network connectivity features, estimated from CCN and DMN, show promise as a predictive biomarker of the ECT outcome of DEP patients. Also, this study identifies a possible underlying mechanism associated with the ECT effect on DEP patients. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:F. H. Bradley and the Working-out of Absolute Idealism* JOHN HERMAN RANDALL, JR. FRANCIS HERBERTBRADLEY (1846-1924) 1 agreed with the other English idealists that the real world is the experienced world. But he started with the fundamental conviction that "experience" is more than "thought," as Green had maintained. Bradley's basic drive is the refusal to abolish "feeling" in favor of knowledge and intelligibility. "Feeling" is a fundamental and (...) ineradicable aspect of "reality"m more fundamental, in fact, than thinking. In the immediately experienced world, all intelligible distinctions and relations are merged in a "whole of feeling" which is the ultimate subject-matter of philosophy. "Thought" arises out of feeling, out of "immediacy," as an interpretation of immediate experience by distinguishing relations and aspects in it. "Knowledge " is only one aspect of the experienced world; it needs blending with "feeling" and will to include all the experienced aspects. "Feeling" starts for Bradley, in his Principles of Logic (1883), in pretty much the empiricist sense, as isolated sensations, and as subjective (in flavor at least). It then becomes neutral: "feeling" is identified with "the felt"; and it grows richer, attempting to include the whole wealth of immediate experience. Thus Bradley gets very close to Dewey's conception of "direct experience," "non-reflective experience," without, however, Dewey's biological analysis. It is through this conception of experience that Bradley approaches the naturalism to which his thinking almost arrived at the end. Thought, that is, has a setting in experience " it is relational, and by its analysis it breaks up experienced and felt wholes. There is a double insistence in Bradley. On the one hand, reality is experienced, but is not adequately expressed in thought. On the other, reality/s accessible to knowledge. What has often been called Bradley's "skepticism" is really an objective relativism. Thought, logical structure, is not ultimate. In Appearance and *This study of F. It. Bradley is based on one of five chapters on post-ttegehan philosophical Ideahsm in Britain and America to be included in my forthcoming Career oJ Philosophy in Modem Times, Vol.III: The Hundred Years Since Darwin. ISee Bradley ed. of Mind, XXXIV (1925); A. E. Taylor, "F. H. Bradley"; J. H. Muirhead, "Bradley's Place in Philosophy." See also T. M. Forsyth, English Philosophy (London: 1910), chap. VII, 2rid part; Rudolf Kagey, F. H. Bradley's Logic (New York: 1931). The best philosophical analyses of Bradley are Robert D. Mack, The Appeal to Immediate Experience (New York: 1945),and Richard Wollheim,F. H. Bradley (Pelican Books, 1959). [245] 246 HISTORY OF PHILOSOPHY Reality, he insists it is really self-contradictory; then later he emphasizes rather that it is always relative to its particular subiect-matter. The real, experienced world is never identical with the intelligible world, yet it is also never "extraneous " to it. The relation of the two can be said to be, in Aristotelian terms, that of substance to form, that of what is to its intelligible aspect. The intelligible world, the system of science and knowledge, thus fundamentally needs criticism in the light of its setting in the experienced world. This is not only the entire drive of Dewey's Experience and Nature; it is the expression of that whole current of thought on the Continent which began with the criticism of Hegel's "panlogism" in the 1840's and is today called "Existentialism." Bradley is the British counterpart of all those who have criticized philosophies of logical structure like T. H. Green's, or like the other contemporary forms of Neo-Kantianism in Germany and France. The "known world" is a world of relations distingflished in the richer "real world." These distinctions are ultimately relative to their particular setting, but in that setting they are valid enough. Bradley's celebrated doctrine of the "degrees of truth and reality" means that practically knowledge is "true"; any idea which fulfills its purpose of rendering some portion or aspect of experience intelligible and significant and meaningful, and which is not ousted by a better idea, Bradley is willing to say is "so far true." It is valid, in its own sphere and purpose, despite its ultimate inconsistency; the wave-theory... (shrink)

A goal-oriented analysis of argument is presented based on Taylor's layered protocols, a theory of communication based on Powers' hierarchical perceptual control theory. Goals and beliefs are hierarchical, related in a precise way to sensory inputs an d motor outputs. This model is combined with Gilbert's theory of coalescent argumentation. Participants sketch out their own and their partner's goal diagrams as an aid to resolving the argument. For this to work, the argument must be viewed, not in pu rely linguistic (...) or logical terms, but in terms of the entire system of goals in which it is embedded. (shrink)

While the essays on this web site, taken together, explain most of the essentials of my metaphysical system, some material is not covered, and the different essays take quite different approaches. The essays were mostly written for undergraduate and graduate courses in philosophy at the University of Toronto and York University. Thus, each essay is slanted to the issues that were addressed in whatever course it was written for. However, I hope soon to pull all this material together into a (...) cohesive, single work that will explain my system more fully and with more focus, which will serve as my Ph.D. dissertation. In the meantime this brief overview gives the broad picture of what my philosophical system is, and how the various essays on these pages are inter-related. For those who do not wish to read through this entire page, the Quantum Phenomenology essay is probably the one you should read if you only have time to read one, as it is the closest to being comprehensive. (shrink)

Skeptical of the arguments put forth in Robert Duncan's long-awaited, post-humously published The H. D. Book, this review essay questions the elevation of Pre-Raphaelite, Aestheticist, and Decadent poetry that forms the basis of Duncan's revisionist canon—a revision in which Wallace Stevens and T. S. Eliot are dismissed as “merely rational,” while H. D. and Duncan himself are elevated to the uppermost ranks, just beneath Ezra Pound. The essay focuses on the peculiarity of “Wardour Street” diction returning to poetry in the (...) postmodern era (especially in the verse of Gjertrud Schnackenberg) and connects this development to the nostalgia evidenced in Duncan's occultism. Placing the New Critics with the poets Karl Shapiro and Richard Wilbur, Duncan dismisses them all as “academics” and “descendants of those ministers of the seventeenth and eighteenth century, holding out against the magic of poetry as once they held out against the magic-religion of witch cults.” Emphasizing that it is the witch cults with which Duncan evidently sides, the essay concludes that Duncan's reranking of poets is no more reliable than his attitude toward rationality. (shrink)

We are immersed within an odorous sea of chemical currents that we parse into individual odors with complex structures. Odors have been posited as determined by the structural relation between the molecules that compose the chemical compounds and their interactions with the receptor site. But, naturally occurring smells are parsed from gaseous odor plumes. To give a comprehensive account of the nature of odors the chemosciences must account for these large distributed entities as well. We offer a focused review of (...) what is known about the perception of odor plumes for olfactory navigation and tracking, which we then connect to what is known about the role odorants play as properties of the plume in determining odor identity with respect to odor quality. We end by motivating our central claim that more research needs to be conducted on the role that odorants play within the odor plume in determining odor identity. (shrink)

For more than a quarter of a century, Hubert L. Dreyfus has been the leading voice in American philosophy for the continuing relevance of phenomenology, particularly as developed by Edmund Husserl, Martin Heidegger, and Maurice Merleau-Ponty. Dreyfus has influenced a generation of students and a wide range of colleagues, and these volumes are an excellent representation of the extent and depth of that influence.In keeping with Dreyfus's openness to others' ideas, many of the essays in this volume take the form (...) of arguments with various of his positions. The essays focus on the dialogue with the continental philosophical tradition, in particular the work of Heidegger, that has played a foundational role in Dreyfus's thinking. The sections are Philosophy and Authenticity; Modernity, Self, and the World; and Heideggerian Encounters. The book concludes with Dreyfus's responses to the essays.Contributors : William D. Blattner, Taylor Carman, David R. Cerbone, Dagfinn Føllesdal, Charles Guignon, Michel Haar, Beatrice Han, Alastair Hannay, John Haugeland, Randall Havas, Jeff Malpas, Mark Okrent, Richard Rorty, Julian Young, Michael E. Zimmerman. (shrink)